What is difference between glycogenolysis and gluconeogenesis?
Glycogenolysis and Gluconeogenesis are two types of processes occurring in the liver to release glucose into blood.
Glycogenolysis, as name specifies is the breakdown of glycogen to release glucose molecules. Glycogen in the muscle cells and liver cells is broken down under the influence of the hormones namely, glucagon and adrenaline.
Gluconeogenesis is the process which results in the formation of glucose from non-carbohydrate sources. It occurs in liver cells consuming more amount of ATP. Gluconeogenesis involves breakdown of proteins stored in the muscles to release amino acids. Amino acids inturn are used in the generation of glucose molecules. Lipids get hydrolysed into glycerol and fatty acids. Glycerol is used to produce glucose molecules. Fatty acids do not form the substrates to form glucose in the process of gluconeogenesis.
| GLYCOGENOLYSIS | GLUCONEOGENESIS |
|---|---|
| It results in the formation of glucose by breaking down glycogen molecules stored in the liver. | It results in the formation of glucose molecules from non-carbohydrate sources. |
| Glycogen is broken down to form Glucose- 6-phosphate. | Amino acids, lactic acids are converted into glucose. |
| It is hydrolytic process. | It is anabolic process. |
| Less amount of ATP is consumed. | 6 molecules of ATP are consumed per 1 glucose molecule synthesised. |