In human male reproductive system, spermatogenesis starts at the age of puberty due to significance increase in the secretion of gonadotropin-releasing hormone from the pituitary gland. The increased level of GnRH then acts on the anteriror pituitary gland and stimulates secretion of the two gonadotropins : LH and FSH. LH acts on leydig cells and stimulates synthesis and secretion of androgens, which stimulates spermatogenesis. FSH acts on the sertoli cells and stimulates secretion of some factors which help in the process of spermatogenesis.
