Drugs like LSD, barbiturates, amphetamines,etc

Drugs like LSD, barbiturates, amphetamines,etc., are used as medicines to help patients with mental illness. However, excessive doses and abusive usage are harmful. Enumerate the major adverse effects of such drugs in humans.

Harmful effects of drugs like LSD, barbiturates, etc., are:
(i) Anxiety, shakiness, nausea and sweating, loss of mind control.
(ii) Reckless behaviour, vandalism and violence.
(iii) Lack of interest in personal hygiene, fluctuations in weight and appetite.
(iv) Social adjustment problems.
(v) Withdrawal, isolation, depression, fatigue, aggressive behaviour.
(vi) Withdrawal symptoms can be severe and life threatening.
(vii) Excessive doses of drugs may lead to coma and death due to respiratory failure, heart failure or cerebral haemorrhage.