The part of life cycle of Plasmodium spent in human body includes following stages:
(i) Sporozoites enter the human body through the bite of infected female Anopheles mosquito (vector).
(ii) From the blood, they enter liver cells and multiply within the liver cells.
(iii) Infected liver cells burst and release the parasites again in the blood.
(iv) They attack RBCs repeatedly, multiply and cause their rupture.
(v) Ruptured RBCs release a toxin called haemozoin which is responsible for high recurring fever and resultant chill/shivering.
(vi) When a female Anopheles mosquito bites an infected person, these parasites enter the mosquito body and undergo further development.